First and foremost P4 is the main menu, so I started with leaving it as is along with its Menu Button counterparts.
Now the Button settings for normal cruising down the road. Granted these are my preferences for reasons explained. Your mileage, and or desires may vary. The principle factor for me is eyes-on-road, not on radio operation.
In keeping with the Menu Prior & Next Setting, I wanted P2 and P3 to serve as Prior Zone (down), or Next Zone(up).
Without two knobs on the radio, I want my sole knob to serve as channel selector in order to dial my way up or down through the channels one by one with a twist of P8. Having now dedicated that knob to channel activities, I also set the P7 (Push-In) to trigger scan on and off with the channels in the zone I am dialed into.